Clinical Failures of Linezolid and Implications for the Clinical Microbiology Laboratory
نویسندگان
چکیده
inezolid is the first in a new class of antimicrobials, the oxazolidinones. This antimicrobial is approved to treat gram-positive infections caused by vancomycin-resistant enterococci (VRE) and methicillin-resistant Staphylococcus aureus (MRSA) (1). Newer antibiotics have provided clinicians greater treatment options; however, ongoing experience shows limitations in their use. We report two patients with infections caused by linezolid-resistant and possible linezolidnonsusceptible bacteria and provide commentary on the increasing bacterial resistance to linezolid and quinupristin/ dalfopristin, as well as the appropriate use of these and future antibiotics.
منابع مشابه
Quality Costs in Clinical Laboratory
Introduction: The concept quality cost for all clinical laboratories perform routine and specialized tests of any size and scope has many applications. Familiarity of managers and employees of clinical laboratories with quality cost concept prevent wasted resources and offers laboratory services with high quality to physicians, patients, and other internal and external customers with reasonable...
متن کاملAntibiotic Susceptibility of Staphylococcus aureus and Enterococcus Spp. Isolated from some Hospitals in Tehran
Abstract Background and Objective: Vancomycin-resistant enterococci (VRE) and methicillin-resistant Staphylococcus aureus (MRSA) are the leading nosocomial pathogens in Iran. We aimed at evaluating the resistance patterns of Staphylococcus aureus and enterococci to the antibiotics recommended by Clinical and Laboratory Standards Institute (CLSI). Material and Methods: Two-hu...
متن کاملDetection of Methicillin-resistant Staphylococcus aureus according to mecA and femA Genes Among Hospitalized Patients in Kashan and Isfahan Hospitals
Background and Aim: Increased prevalence of methicillin-resistant Staphylococcus aureus (MRSA) and treatment of infections due to these resistant strains is one of the most important health challenges. In this study, antimicrobial resistance patterns of Staphylococcus aureus isolates from patients were determined to commonly prescribed and last-resort antibiotics, and methicillin-resistant Stap...
متن کاملRevision of linezolid disk diffusion quality control guidelines for testing Staphylococcus aureus ATCC 25923: an independent seven-laboratory trial.
The accuracy of the published disk diffusion quality control (QC) range for linezolid for Staphylococcus aureus ATCC 25923 has been reported to be problematic, prompting a multicenter study to determine if revision was necessary. Five out of seven laboratories reported values outside the current QC range. Three participants had significant (13.3-60.0%) 'unacceptable' results with zones smaller ...
متن کاملHuman Laboratory Settings for Assessing Drug Craving Implications for the Evaluation of Treatment Efficacy
Research on assessing craving in laboratory settings often involves inducing and then measuring craving in subjects. Cue-induced craving is studied in laboratory settings using the cue reactivity paradigm, in which drug-related photos, videos, evocative scripts, olfactory cues, and paraphernalia may induce craving. Cue-induced craving evoked by drug-related stimuli could be associated with rela...
متن کامل